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Similase GFCF DPP-IV Gluten & Casein Digestive Enzymes


If you’ve ever felt extremely tired, lethargic, or spacey with brain-fog after eating this might be the right digestive enzyme for you.  Similase GFCF is a specialty digestive enzyme containing DPP-IV.  It is formulated for those with food allergies & sensitivities.  DPP-IV deficiency, damage, or decreased enzymatic activity, has been tied to many neurological diseases like Autism, immune dysfunction, eating, depressive & psychiatric disorders.

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Why Similase GFCF Digestive Enzyme?

Complete digestion of gluten and casein can be particularly difficult for some people. My research & years of personal experience suggest that children are often more sensitive to these foods.  They are very common problems with children on the Autism Spectrum.  But Similase GFCF with DPP-IV by Integrative Therapeutics is a great way to fight back against the opioid affect.

When not broken down completely these partially digested long protein chains can cause a wide range of harmful effects to the body.  Similase GFCF contains enzymes to support complete & comprehensive digestion.  Its primary function is to break down these difficult polypeptide protein chains.

Similase GFCF provides dipeptidyl peptidase IV (DPP IV) activity.  An extremely important enzyme for the digestion of proline-containing dipeptides from gluten and casein.*  Similase GFCF helps to support a gluten-free, casein-free lifestyle or those who are especially sensitive to these special protein chains.  It also helps with general digestion to relieve occasional indigestion, gas, and bloating.*

Similase GFCF works in a unique way to specifically break apart proline-containing peptides found in dairy & glutenous cereal grains.  When improperly digested these foods can produce opiate peptides.  These are gluteomorphin / gliadorphin & casomorphin.  They can react to & mimic strong opioids like morphine, heroin, or oxycontin etc.

This is the first thing I muscle test & my preferred digestive enzyme to for those with food allergies, sensitivities, auto-immune disease, any neurological, cognitive, psychological or psychiatric disorders.  That is because Dipeptidyl Peptidase IV or DPP-IV regulates many physiological responses & processes.  DPP-IV enzymatic activity regulates things like; growth, pain responses (either lacking or pain response looping), immunological functioning & responses to infection, desire to eat, appetite control, & complete digestion.

DPP-IV Deficiency or Insufficiency Ties to Diseases & Disorders

Dipeptidyl Peptidase IV (DPP-IV) deficiency, insufficiency or decreased enzymatic activity has ties to a wide range of diseases.  Many of these are psychiatric & mental health in nature.  Also, many times the level of deficiency directly ties to the severity of the disorder.  But also, many autoimmune, digestive, immunological including some forms of cancers.

  • Alcoholism
  • Alzheimer’s
  • Arthritis
  • Autism / ASD / Asperger’s
  • Cancers (Oral, Skin & Prostate)
  • COPD
  • Crohn’s
  • Depression (Major & Bipolar)
  • Eating Disorders (Anorexia & Bulimia)
  • Fibromyalgia & Other Types of Nerve Pain
  • Lupus
  • Pregnancy (Decreased During – More Problematic for Mother’s with Autoimmune Diseases)
  • Psychosis

Digestive Enzymes May Greatly Improve These Issues…

  • Heartburn
  • Constipation
  • Bloating
  • Chronic Illness
  • Lactose Intolerance
  • Acid Re-flux
  • Food Allergies
  • Overall Health
  • Weight Loss
  • Energy


Benefits Of Similase GFCF

  • Complete Digestion of Polypeptide Protein Chains as Well as Basic Digestion of Fats, Carbs & Protein
  • May Help Reduce or Prevent Substance P which Affect Pain Responses
  • Provides the Best Level of Support For & Against Food Allergies & Sensitivities
  • May Help Block or Prevent the Formation of Opioid Substances Effecting Neurological & Cognitive Functioning


Microbial Enzymes - 621 mg

DPP IV Protease Blend

(Protease I, II, III, IV, V):
FCC (pH 4.7) 134,660 HUT,
FCC (pH 7.0) 22,660 PC,
USP (pH 7.5) 12,557 USP

FCC (pH 4.6) 16,370 DP°,
FCC (pH 4.8) 16,370 DU,
USP (pH 6.8) 10,913 USP

Lactase I, II: FCC (pH 4.5) 642 ALU
Lipase I, II: FCC (pH 7.0) 888 FIP
Cellulase I, II: FCC (pH 4.5) 141 CU
Sucrase (Invertase): FCC (pH 4.5) 181 SU
Phytase: FCC (pH 5.5) 0.68 FTU

Other Ingredients:

hydroxypropyl methylcellulose (vegetable capsule), cellulose, inulin (from chicory root), calcium laurate, silicon dioxide

Does Not Contain:

Dairy Products
Artificial Colors
Artificial Flavors
Ingredients of animal origin

Recommended Use:

Adults: Take 1-2 capsules with each meal, Children: 1/4 - 1 capsule opened & poured in juice, water, milk or milk substitute or stirred in non-hot food like yogurt or applesauce. Or as muscle tested or recommended by your healthcare professional.


If you are pregnant, nursing, have diabetes, or if you are taking prescription drugs, consult your healthcare professional prior to use. While Similase® GFCF will reduce the level of reactive gliadin and gluten proteins in a meal, it is advised that celiac disease sufferers continue with their normal gluten exclusion diet as even small amounts of gliadin can cause adverse reactions in the most sensitized individuals.Keep out of reach of children.

Other Details About Similase GFCF

SKU: 73952
UPC: 871791003866


Additional information

Weight5 oz

Expiration Date



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